منابع مشابه
Vision restoration therapy: confounded by eye movements.
Indocyanine green-assisted peeling of the internal limiting membrane may cause retinal damage. Am J Ophthalmol 2001;132:431–3. 29 Gandorfer A, Haritoglou C, Gandorfer A, et al. Retinal damage from indocyanine green in experimental macular surgery. Invest Ophthalmol Vis Sci 2003;44:316–23. 30 Rezai KA, Farrokh-Siar L, Ernest JT, et al. Indocyanine green induces apoptosis in human retinal pigment...
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In this issue of Neuron, Tochitsky et al. (2016) have identified the mechanism by which small-molecule photoswitches enter and specifically activate retinal OFF-ganglion cells in degenerated retinas. This drug development is a tremendous step toward the treatment of blindness, regardless of the underlying mutation.
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800x600 unfortunately, at present, degenerative retinal diseases such as retinitis pigmentosa remains untreatable. patients with these conditions suffer progressive visual decline resulting from continuing loss of photoreceptor cells and outer nuclear layers. however, stem cell therapy is a promising approach to restore visual function in eyes with degenerative retinal diseases such as retiniti...
متن کاملPhotochemical approaches to vision restoration
Photoswitches are traditional pharmacologic agonists, antagonists, or channel blockers that are covalently modified with an azobenzene derivative. Azobenzene undergoes wavelength-dependent isomerization between cis and trans conformation. For some photoswitches, only one of these configurations is biologically active, resulting in light-dependent activation or inhibition of function. Photoswitc...
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BACKGROUND Optic neuritis is a frequent manifestation of multiple sclerosis. Visual deficits range from a minor impairment of visual functions through to complete loss of vision. Although many patients recover almost completely, roughly 35% of patients remain visually impaired for years, and therapeutic options for those patients hardly exist. Vision restoration therapy is a software-based visu...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2005
ISSN: 0007-1161
DOI: 10.1136/bjo.2005.068163